Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11491980 | 0.90 | MAPT (0.62) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL1466483 | 0.88 | CRHBP (0.65) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL8061795 | 0.85 | LMNA (0.57) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL10322740 | 0.84 | CES2 (0.60) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL6312189 | 0.84 | MITF (0.64) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL11091089 | 0.83 | CTSV (0.57) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL2972277 | 0.83 | LMNA (0.57) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL1250743 | 0.82 | MAPT (0.54) | MAPTKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL6813421 | 0.82 | ALDH1A1 (0.69) | MAPTKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL29953088 | 0.82 | MAPT (0.54) | MAPTKDM4EKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |