Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27650116 | 0.90 | MET (0.51) | METMAP4K3FYNMAP4K4INPPL1 | |
| SCHEMBL27629924 | 0.86 | MET (0.56) | METJAK2MAP4K3FYNMAP4K4 | |
| SCHEMBL487782 | 0.86 | MET (0.65) | METJAK2MAP4K3FYNRAB9A | |
| SCHEMBL30453255 | 0.86 | MET (0.65) | METJAK2MAP4K3FYNRAB9A | |
| SCHEMBL487833 | 0.85 | JAK2 (0.58) | METJAK2MAP4K3FYNRAB9A | |
| SCHEMBL30452968 | 0.81 | MAP4K4 (0.64) | METJAK2MAP4K4 | |
| SCHEMBL487734 | 0.81 | MAP4K4 (0.64) | METJAK2MAP4K4 | |
| SCHEMBL27630129 | 0.81 | MET (0.74) | METJAK2MAP4K3FYNMAP4K4 | |
| SCHEMBL27630135 | 0.81 | MET (0.64) | METJAK2MAP4K3FYNRAB9A | |
| SCHEMBL27630181 | 0.80 | MET (0.51) | METJAK2MAP4K3FYNMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | claimed |
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | disclosed |