SCHEMBL27645545

SCHEMBL27645545

CC(C)(Cl)C(=O)c1ccc(C(Br)Br)cc1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 3/20 0.35
MLYCD O95822 4/20 0.33
POLB P06746 2/20 0.32
NR1H4 Q96RI1 2/20 0.32
HPGD P15428 1/20 0.32
CA2 P00918 1/20 0.32
ALDH1A1 P00352 2/20 0.31
KMT2A Q03164 2/20 0.31
LMNA P02545 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CYP2C9 P11712 2/20 0.31
MEN1 O00255 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL480373 0.89 GSK3B (0.35) GSK3BMLYCDPOLBNR1H4HPGD
SCHEMBL3669531 0.88 MLYCD (0.34) GSK3BMLYCDNR1H4CA2ALDH1A1
SCHEMBL27625178 0.87 MLYCD (0.36) GSK3BMLYCDPOLBNR1H4HPGD
SCHEMBL11679589 0.84 PGR (0.38) GSK3BMLYCDNR1H4CA2ALDH1A1
SCHEMBL3671272 0.82 CA2 (0.36) GSK3BMLYCDNR1H4HPGDCA2
SCHEMBL6448136 0.82 ESR1 (0.41) MLYCDPOLBNR1H4HPGDALDH1A1
SCHEMBL10752558 0.82 CYP2C9 (0.47) POLBHPGDALDH1A1KMT2ALMNA
SCHEMBL4427192 0.78 RARA (0.35) MLYCDALDH1A1KMT2ATSHRMEN1
SCHEMBL480646 0.77 ACHE (0.36) GSK3BHPGDALDH1A1KMT2ALMNA
SCHEMBL4421929 0.77 ALDH1A1 (0.48) HPGDALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1784429-B Novel trifunctional photoinitiators CIBA SC HOLDING AG 2010-06-02 CN disclosed
CN-1784429-A Novel trifunctional photoinitiators CIBA SC HOLDING AG (CH) 2006-06-07 CN disclosed