Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27649623 | 0.95 | ADRA2C (0.50) | ADRA2CFLT3ADORA2AADORA1AURKA | |
| SCHEMBL27649425 | 0.87 | ALDH1A1 (0.54) | MAPKAPK2KDM4EMAPTALDH1A1JAK2 | |
| SCHEMBL4015250 | 0.84 | ADRA2C (0.49) | ADRA2CADORA2AADORA1AURKAMELK | |
| SCHEMBL27669648 | 0.83 | HTR6 (0.44) | ADORA2AADORA1MAPKAPK2MELKKDM4E | |
| SCHEMBL27649645 | 0.81 | AURKA (0.43) | ADRA2CADORA2AADORA1AURKAMELK | |
| SCHEMBL27649461 | 0.76 | KDM4E (0.48) | KDM4EGAAMAPTALDH1A1KMT2A | |
| SCHEMBL27669721 | 0.75 | MAP4K1 (0.49) | KDM4EALDH1A1KMT2AMAP4K1JAK2 | |
| SCHEMBL28845811 | 0.73 | ADRA2C (0.70) | ADRA2CFLT3MAPKAPK2MELKAGXT | |
| SCHEMBL27649830 | 0.73 | HTR6 (0.45) | ADRA2CMELKAGXT | |
| SCHEMBL28470068 | 0.72 | ALK (0.51) | KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | claimed |
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |