Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015250 | 0.87 | ADRA2C (0.49) | KDM4EALDH1A1MAPTMAP4K1FYN | |
| SCHEMBL27649425 | 0.83 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTHTR6NPC1 | |
| SCHEMBL27649623 | 0.81 | ADRA2C (0.50) | KDM4EALDH1A1MAPTMAP4K1LCK | |
| SCHEMBL27669721 | 0.81 | MAP4K1 (0.49) | KDM4EALDH1A1MAP4K1HTR6HPGD | |
| SCHEMBL27669648 | 0.80 | HTR6 (0.44) | KDM4EALDH1A1HTR6HRH4NPC1 | |
| SCHEMBL27649645 | 0.77 | AURKA (0.43) | KDM4EALDH1A1MAPTMAP4K1HTR6 | |
| SCHEMBL27669767 | 0.76 | ADRA2C (0.50) | KDM4EALDH1A1MAPTMAP4K1LCK | |
| SCHEMBL28470068 | 0.75 | ALK (0.51) | KDM4EALDH1A1MAPTFYNHRH4 | |
| SCHEMBL424503 | 0.72 | DRD2 (0.66) | KDM4EALDH1A1MAPTFYNL3MBTL1 | |
| SCHEMBL27649830 | 0.71 | HTR6 (0.45) | HTR6HRH4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | claimed |
| CN-1909908-A | Pyrazolo [1, 5-a ] pyrimidin-7-yl-amine derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |