Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27649623 | 0.88 | ADRA2C (0.50) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL28470068 | 0.87 | ALK (0.51) | KDM4EMAPTALDH1A1HRH4FYN | |
| SCHEMBL27649461 | 0.87 | KDM4E (0.48) | KDM4EGAAMAPTALDH1A1KMT2A | |
| SCHEMBL27669767 | 0.84 | ADRA2C (0.50) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL27649645 | 0.82 | AURKA (0.43) | ADRA2CKDM4EGAAMAPTPTK2B | |
| SCHEMBL27669648 | 0.81 | HTR6 (0.44) | KDM4EGAAALDH1A1GFERJAK2 | |
| SCHEMBL27669721 | 0.77 | MAP4K1 (0.49) | KDM4EALDH1A1KMT2AJAK2MAP4K1 | |
| SCHEMBL27649425 | 0.75 | ALDH1A1 (0.54) | KDM4EMAPTALDH1A1JAK2MAPK1 | |
| SCHEMBL27649830 | 0.72 | HTR6 (0.45) | ADRA2CHRH4MELK | |
| SCHEMBL2385795 | 0.71 | HRH4 (0.64) | ADRA2CKDM4EGAAMAPTPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074127-A1 | PYRAZOLO [1, 5-A]PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008037459-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |