Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015250 | 0.87 | ADRA2C (0.49) | FYNTGFBR1ACVR1KDM4EALDH1A1 | |
| SCHEMBL27649623 | 0.76 | ADRA2C (0.50) | KDM4EALDH1A1MAPT | |
| SCHEMBL27649461 | 0.75 | KDM4E (0.48) | ALKFYNTGFBR1ACVR1KDM4E | |
| SCHEMBL27669767 | 0.72 | ADRA2C (0.50) | KDM4EALDH1A1MAPT | |
| SCHEMBL188924 | 0.72 | MAPT (0.67) | ALKFYNHRH3ESRRGKDM4E | |
| SCHEMBL27649645 | 0.70 | AURKA (0.43) | KDM4EALDH1A1MAPT | |
| SCHEMBL27669648 | 0.69 | HTR6 (0.44) | KCNH2KDM4EALDH1A1HRH4 | |
| SCHEMBL24618822 | 0.66 | MAPT (0.60) | ALKFYNHRH3ESRRGKDM4E | |
| SCHEMBL28476087 | 0.66 | ALK (0.69) | ALKFYNHRH3KDM4EALDH1A1 | |
| SCHEMBL31047544 | 0.66 | ALK (0.41) | ALKFYNTGFBR1ACVR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774224-B | Pyrazolo [3,4-b ] pyridine compound and preparation method and application thereof | 浙江大学 | 2020-10-30 | — | — | CN | claimed |