Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017613 | 0.85 | HSD17B10 (0.58) | ALDH1A1MAPTLMNAHPGDHTT | |
| SCHEMBL30565841 | 0.82 | PLCG1 (0.52) | ALDH1A1LMNAHTTL3MBTL1MEN1 | |
| SCHEMBL9845538 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTLMNAHPGDHTT | |
| SCHEMBL10728701 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNAHPGDHTT | |
| SCHEMBL27595261 | 0.79 | MAOA (0.47) | ALDH1A1MAPTLMNAHPGDHTT | |
| SCHEMBL8993328 | 0.78 | NFE2L2 (0.49) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL4685419 | 0.78 | NFE2L2 (0.49) | LMNAHTTNPC1RAB9AKEAP1 | |
| SCHEMBL30333699 | 0.78 | NFE2L2 (0.49) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL28152198 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAHPGDHTT | |
| SCHEMBL1015140 | 0.77 | PKM (0.55) | ALDH1A1MAPTHPGDHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710467-A | Photooxidation reduction protein modification | 罗莎琳德·富兰克林研究所 | 2023-09-05 | — | — | CN | disclosed |
| CN-106831551-B | A kind of method that ionic liquid method synthesizes the halogenated -3- substituted hydrocarbon radical sulfonyl pyridine of 2- and its intermediate | 山东师范大学 | 2019-09-24 | — | — | CN | disclosed |
| CN-106748988-B | A kind of method that supercritical ultrasonics technology synthesizes the halogenated -3- substituted hydrocarbon radical sulfonyl pyridine of 2- and its intermediate | 山东师范大学 | 2019-05-28 | — | — | CN | disclosed |
| CN-106866515-B | A kind of sulfonyl pyridine derivative and its synthetic method | 山东师范大学 | 2019-05-28 | — | — | CN | disclosed |
| CN-106866514-B | A kind of method that Aqueous phase synthesizes the halogenated -3- substituted hydrocarbon radical sulfonyl pyridine of 2- and its intermediate | 山东师范大学 | 2019-05-28 | — | — | CN | disclosed |
| CN-106518757-B | A kind of method that microwave method synthesizes the halogenated -3- substituted hydrocarbon radical sulfonyl pyridine of 2- and its intermediate | 山东师范大学 | 2019-03-19 | — | — | CN | disclosed |
| US-10173993-B2 | Process for the synthesis of sulfones and sulfonamides | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2019-01-08 | — | — | US | disclosed |
| CN-106866515-A | A kind of sulfonyl pyridine derivative and its synthetic method | 山东师范大学 | 2017-06-20 | — | — | CN | disclosed |
| CN-106866514-A | A kind of method of the Aqueous phase synthesis substituted hydrocarbon radical sulfonyl pyridine of 2 halo 3 and its intermediate | 山东师范大学 | 2017-06-20 | — | — | CN | disclosed |
| US-20170166542-A1 | Process for the Synthesis of Sulfones and Sulfonamides | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2017-06-15 | — | — | US | disclosed |
| EP-1551797-A1 | CYCLOHEXYL SULPHONE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2005-07-13 | — | — | EP | disclosed |
| EP-1551799-A1 | CYCLOHEXYL SULPHONES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2005-07-13 | — | — | EP | disclosed |
| US-6890956-B2 | Cyclohexyl sulphones as gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2005-05-10 | — | — | US | disclosed |
| US-20040122050-A1 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2004-06-24 | — | — | US | disclosed |
| US-20040121995-A1 | Cyclohexyl sulphones as gamma-secretase inhibitors | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2004-06-24 | — | — | US | disclosed |
| WO-2004031137-A1 | CYCLOHEXYL SULPHONE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |
| WO-2004031139-A1 | CYCLOHEXYL SULPHONES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |
| US-4456470-A | Herbicidal 2-(alpha-chloromethylsulfonyl) pyridine-1-oxides | UNIROYAL, INC. (US) | 1984-06-26 | — | — | US | disclosed |
| EP-0103660-A1 | Pyridine-1-oxides, herbicidal compositions thereof and herbicidal methods for applying the compounds | UNIROYAL, INC. (US) | 1984-03-28 | — | — | EP | disclosed |
| US-4360677-A | Herbicidal 2-(alpha-chloromethylsulfonyl) pyridine-1-oxides | UNIROYAL, INC. (US) | 1982-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166542-A1 | Process for the Synthesis of Sulfones and Sulfonamides | STS, SULT2A1, TST | ALDH1A1 2456/4885MAPT 4101/4885LMNA 4315/4885 |
| US-20040122050-A1 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors | BACE1, BACE2, APP | ALDH1A1 1283/4885MAPT 229/4885LMNA 1703/4885 |
| US-10173993-B2 | Process for the synthesis of sulfones and sulfonamides | STS, SULT2A1, TST | ALDH1A1 2456/4885MAPT 4101/4885LMNA 4315/4885 |
| US-20040121995-A1 | Cyclohexyl sulphones as gamma-secretase inhibitors | BACE1, BACE2, APP | ALDH1A1 1531/4885MAPT 164/4885LMNA 1696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.