Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587166 | 0.82 | GABRA1 (0.48) | PDE4APDE4BPDE4CPDE4DPTGS1 | |
| SCHEMBL27711656 | 0.79 | PDE4B (0.39) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL27800576 | 0.73 | MEN1 (0.36) | PTGS2PTGS1MAPTKDM4EGAA | |
| SCHEMBL1535884 | 0.72 | BACE1 (0.54) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL27691694 | 0.72 | ADRB2 (0.39) | PTGS2PTGS1KDM4EGAARECQL | |
| SCHEMBL27691525 | 0.72 | PTGS1 (0.33) | PTGS2PTGS1KDM4EGAARECQL | |
| SCHEMBL27831460 | 0.72 | PTGS1 (0.33) | PTGS2PTGS1KDM4EPOLBGAA | |
| SCHEMBL27686304 | 0.72 | MAPK1 (0.35) | PTGS2PTGS1MAPTKDM4EGAA | |
| SCHEMBL31275930 | 0.71 | ALOX5 (0.46) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL9348187 | 0.71 | ALOX5 (0.46) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955470-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-06-13 | — | — | CN | disclosed |
| CN-101061105-B | Potentiators of glutamate receptors | LILLY CO ELI | 2012-05-30 | — | — | CN | disclosed |
| CN-101955470-A | Glutamate receptor potentiators | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| CN-101061106-B | Glutamate receptor potentiators | LILLY CO ELI | 2010-09-29 | — | — | CN | disclosed |
| CN-101061105-A | Potentiators of glutamate receptors | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |
| CN-101061106-A | Glutamate receptor potentiators | LILLY CO ELI (US) | 2007-10-24 | — | — | CN | disclosed |