Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RBP4 | P02753 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28746134 | 0.79 | GOT1 (0.33) | MEN1KMT2ALMNAALDH1A1MAPT | |
| SCHEMBL30062550 | 0.78 | GPR119 (0.52) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1928396 | 0.78 | GPR119 (0.52) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28762854 | 0.78 | ADRA2C (0.39) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28840342 | 0.75 | POLB (0.42) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL30937462 | 0.72 | ALDH1A1 (0.59) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL18600520 | 0.72 | ALDH1A1 (0.59) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28794456 | 0.71 | MEN1 (0.39) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25389057 | 0.71 | NCF1 (0.55) | MEN1KMT2AALDH1A1HTTHTR1A | |
| SCHEMBL28866522 | 0.70 | KDM4E (0.33) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109912514-A | (2- heteroaryl aminocarbonyl phenyl) azepine ring derivatives and application thereof | 广东东阳光药业有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-106458943-B | Synthesis of vortioxetine via (2, 4-dimethylphenyl) (2-iodophenyl) sulfane intermediate | 斯洛文尼亚莱柯制药股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-106279071-B | Phenylpiperazine derivatives and its application method and purposes | 广东东阳光药业有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-106458943-A | Synthesis of vortioxetine via (2, 4-dimethylphenyl) (2-iodophenyl) sulfane intermediate | 斯洛文尼亚莱柯制药股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106279071-A | Phenylpiperazine derivatives and using method thereof and purposes | 广东东阳光药业有限公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-106103419-A | Method for synthesizing vortioxetine through (2- (piperazine-1-yl) phenyl) aniline intermediate | 斯洛文尼亚莱柯制药股份有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105939995-A | Synthesis of vortioxetine via (2-(piperazine-1 -yl)phenvl)lithium intermediates | 斯洛文尼亚莱柯制药股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-105348204-A | 1-heterocyclyl-2-(heteroarylthio) benzene derivative and use method and application | RUYUAN YAO AUTONOMOUS COUNTY DAZHONG MEDICINE TRADING CO LTD | 2016-02-24 | — | — | CN | disclosed |
| CN-105339361-A | Novel process for the synthesis of 1- (2- ((2, 4-dimethylphenyl) thio) phenyl) piperazine | LEK PHARMACEUTICALS | 2016-02-17 | — | — | CN | disclosed |
| CN-105283442-A | New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine | LEK PHARMACEUTICALS | 2016-01-27 | — | — | CN | disclosed |
| CN-104829558-A | Preparation method for diaryl thioether amine compound | JIANGSU HANSOH PHARMACEUTICAL | 2015-08-12 | — | — | CN | disclosed |
| CN-101830867-A | Preparation method of 2- (3,3,5, 5-tetramethylcyclohexyl) aniline | EISAI R&D MAN CO LTD | 2010-09-15 | — | — | CN | disclosed |
| CN-101146760-A | Intermediate for producing [ 2- (3,3,5, 5-tetramethylcyclohexyl) phenyl ] piperazine compound | EISAI R&D MAN CO LTD (JP) | 2008-03-19 | — | — | CN | disclosed |