Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27701244 | 0.84 | SLC22A12 (0.44) | SLC22A12PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3604215 | 0.80 | SLC22A12 (0.44) | NLRP3SLC22A12POLBSSTR5 | |
| SCHEMBL7382833 | 0.80 | SLC22A12 (0.56) | SLC22A12POLBSSTR5 | |
| SCHEMBL28772830 | 0.78 | SLC22A12 (0.39) | SLC22A12 | |
| SCHEMBL27701259 | 0.78 | REN (0.41) | SLC22A12POLBPSEN1PSEN2APH1B | |
| SCHEMBL27701262 | 0.78 | CMKLR1 (0.42) | CMKLR1 | |
| SCHEMBL7981706 | 0.76 | KDM4E (0.44) | NLRP3SLC22A12POLBSSTR5 | |
| SCHEMBL705011 | 0.76 | NLRP3 (0.47) | NLRP3SLC22A12POLB | |
| SCHEMBL23467057 | 0.74 | HCAR3 (0.51) | SLC22A12POLBSSTR5 | |
| SCHEMBL26997341 | 0.73 | TMEM97 (0.34) | NLRP3SLC22A12POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101166733-A | Pyrazole derivatives as phosphodiesterase 4 inhibitors | MEMORY PHARM CORP (US) | 2008-04-23 | — | — | CN | disclosed |