Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TERT | O14746 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28436430 | 0.87 | MAPT (0.40) | MAPTALDH1A1HTTSMN1; SMN2PRKCZ | |
| SCHEMBL28433432 | 0.84 | MAPT (0.38) | MAPTALDH1A1HTTSMN1; SMN2PRKCZ | |
| SCHEMBL29018666 | 0.82 | NR3C2 (0.41) | MAPTALDH1A1HTTSMN1; SMN2NR3C2 | |
| SCHEMBL28523211 | 0.75 | KMT2A (0.47) | MAPTALDH1A1SMN1; SMN2PRKCZKDM4E | |
| SCHEMBL28776773 | 0.72 | TERT (0.32) | MAPTALDH1A1HTTSMN1; SMN2TERT | |
| SCHEMBL28897005 | 0.70 | HSD17B10 (0.41) | MAPTALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL5693257 | 0.69 | PTGS2 (0.66) | MAPTALDH1A1HTTSMN1; SMN2KDM4E | |
| SCHEMBL5858831 | 0.68 | PTGS2 (0.68) | MAPTALDH1A1HTTKDM4EGAA | |
| SCHEMBL28823942 | 0.65 | HRH3 (0.42) | MAPTALDH1A1HTTKDM4ENPSR1 | |
| SCHEMBL29051504 | 0.65 | PTGS1 (0.41) | MAPTALDH1A1PRKCZPDE5APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920753-B | 6-fluoro-dihydropyran [2,3-c ] pyrazole derivative and synthetic method and application thereof | 华南理工大学 | 2023-06-20 | — | — | CN | disclosed |
| CN-101243050-B | Pyrazolone derivatives | HOFFMANN LA ROCHE | 2012-07-04 | — | — | CN | disclosed |
| CN-101243050-A | Pyrazolone derivatives | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |