Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.50 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | AOC2 | O75106 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27717070 | 0.96 | FFAR1 (0.53) | FFAR1SLC5A1SLC5A2PLAAT3PLAAT5 | |
| SCHEMBL17142341 | 0.84 | HDAC1 (0.59) | FFAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| Hydroxyphenyl Propionic Acid SCHEMBL10957822 | 0.81 | ESR1 (0.54) | SLC5A1SLC5A2HPGDHDAC3HDAC4 | |
| SCHEMBL7332325 | 0.80 | FFAR1 (0.58) | FFAR1SLC5A1SLC5A2PLAAT3PLAAT5 | |
| Potassium Ion SCHEMBL10803885 | 0.79 | PLAAT3 (0.54) | FFAR1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL22609241 | 0.79 | PLAAT3 (0.58) | FFAR1SLC5A1SLC5A2PLAAT3PLAAT5 | |
| SCHEMBL9327509 | 0.78 | FFAR1 (0.56) | FFAR1SLC5A1SLC5A2PLAAT3PLAAT5 | |
| Phenyl Propionic Acid SCHEMBL5351527 | 0.78 | HDAC1 (0.70) | FFAR1PLAAT5PLAAT4HDAC3HDAC4 | |
| SCHEMBL193318 | 0.78 | FFAR1 (0.79) | FFAR1SLC5A1SLC5A2PLAAT3PLAAT5 | |
| SCHEMBL27482057 | 0.78 | FFAR1 (0.56) | FFAR1SLC5A1SLC5A2PLAAT3PLAAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101268049-A | Novel piperidine derivatives | ASTRAZENECA AB (SE) | 2008-09-17 | — | — | CN | disclosed |