SCHEMBL2772741

SCHEMBL2772741

CO[Si](C)(CN=C=S)OC.CO[Si](CCCN=C=S)(OC)OC

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 8/20 0.39
NAAA Q02083 1/20 0.36
MIF P14174 4/20 0.34
KEAP1 Q14145 3/20 0.33
NFE2L2 Q16236 3/20 0.33
BACH1 O14867 2/20 0.33
MAFK O60675 2/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
EGFR P00533 1/20 0.33
PTGS2 P35354 1/20 0.33
GSK3B P49841 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL550615 0.88 NAAA (0.45) TRPA1NAAAMIFKEAP1NFE2L2
SCHEMBL551245 0.82 TRPA1 (0.47) TRPA1NAAAMIFKEAP1NFE2L2
SCHEMBL3835195 0.82 NAAA (0.48) TRPA1NAAAMIFKEAP1NFE2L2
SCHEMBL2019741 0.82 TRPA1 (0.33) TRPA1NAAAMIF
SCHEMBL628120 0.80
SCHEMBL15815285 0.78
SCHEMBL6058459 0.74 ALDH1A1 (0.37) TRPA1NAAAALDH1A1
SCHEMBL7955975 0.72
SCHEMBL2772743 0.72 NAAA (0.33) TRPA1NAAA
SCHEMBL8675289 0.72 LMNA (0.35) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2161274-B1 Silane/urea compound as heat-activated hardener for epoxy resin compounds SIKA TECHNOLOGY AG (CH) 2010-05-19 EP disclosed
EP-2161274-A1 Silane/urea compound as heat-activated hardener for epoxy resin compounds Sika Technology AG (CH) 2010-03-10 EP disclosed