Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | GAPDH | P04406 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27437424 | 0.80 | TDP1 (0.35) | CMA1AHRTGM2CES1CYP1A2 | |
| Methylamine SCHEMBL27587572 | 0.78 | KDM4E (0.33) | MEN1KMT2ATDP1 | |
| SCHEMBL29036195 | 0.78 | PDE3B (0.41) | CYP1A2CYP2C19HSPA1APTPN7TDP1 | |
| SCHEMBL6926769 | 0.77 | CREBBP (0.34) | CYP1A2CYP2C19BRD4MEN1KMT2A | |
| SCHEMBL29007498 | 0.76 | KDM4E (0.51) | CYP1A2MEN1KMT2A | |
| SCHEMBL28937477 | 0.76 | ADRA2A (0.36) | CMA1AHRBRD4MEN1KMT2A | |
| SCHEMBL22471500 | 0.75 | BRD4 (0.38) | CMA1AHRTGM2CES1BRD4 | |
| SCHEMBL24290488 | 0.74 | PNMT (0.42) | CMA1AHRBRD4PNMTADRA2A | |
| SCHEMBL16722791 | 0.74 | PNMT (0.42) | CMA1AHRBRD4PNMTADRA2A | |
| SCHEMBL29036205 | 0.73 | CHRNB2 (0.31) | CYP1A2CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437819-B | Pyridopyrazines and derivatives thereof as alk and c-MET inhibitors | CEPHALON INC | 2013-06-19 | — | — | CN | disclosed |
| CN-101437819-A | Pyridopyrazines and derivatives thereof as ALK and c-MET inhibitors | CEPHALON INC (US) | 2009-05-20 | — | — | CN | disclosed |