Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Glyoxylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL1356182 | 0.91 | LMNA (0.48) | BBOX1KMT2AATMALDH1A1LMNA | |
| Acrylic Acid SCHEMBL27587559 | 0.88 | LMNA (0.50) | BBOX1KMT2AATMALDH1A1LMNA | |
| Bicarbonate SCHEMBL2704201 | 0.87 | BBOX1 (0.52) | BBOX1KMT2AATMALDH1A1LMNA | |
| Acrylic Acid SCHEMBL28444109 | 0.86 | LMNA (0.48) | BBOX1KMT2AATMALDH1A1LMNA | |
| Maleic Acid SCHEMBL9664934 | 0.86 | BBOX1 (0.47) | BBOX1KMT2AATMALDH1A1LMNA | |
| Acrylic Acid SCHEMBL20983701 | 0.86 | LMNA (0.48) | BBOX1KMT2AATMALDH1A1LMNA | |
| Bicarbonate SCHEMBL2704202 | 0.83 | BBOX1 (0.59) | BBOX1KMT2AATMALDH1A1LMNA | |
| Acrylic Acid SCHEMBL6467069 | 0.83 | BBOX1 (0.50) | BBOX1KMT2AATMALDH1A1LMNA | |
| Acrylic Acid SCHEMBL1960206 | 0.83 | ALDH1A1 (0.44) | BBOX1KMT2AATMALDH1A1LMNA | |
| Maleic Acid SCHEMBL27845075 | 0.83 | BBOX1 (0.42) | BBOX1KMT2AATMALDH1A1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379098-B | High molecular weight compact structured polymers, methods of making and using | NALCO CO | 2015-03-11 | — | — | CN | disclosed |
| CN-101379098-A | High molecular weight compact structured polymers, methods of making and using | NALCO CO (US) | 2009-03-04 | — | — | CN | disclosed |