Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22627397 | 0.85 | ALDH1A1 (0.47) | ADRA1DKMT2ACSNK2A1ATMCSNK2A2 | |
| SCHEMBL5549902 | 0.85 | ADRA1D (0.52) | ADRA1DKMT2AMKNK1MKNK2ATM | |
| SCHEMBL1293285 | 0.85 | TSHR (0.57) | CSNK2A1CSNK2A2CSNK2BCSNK2A3KLKB1 | |
| SCHEMBL12109847 | 0.83 | ADRA1D (0.51) | ADRA1DKMT2AMKNK1MKNK2ATM | |
| SCHEMBL27618251 | 0.83 | LOXL2 (0.43) | ADRA1DCSNK2A1CSNK2A2CSNK2BCSNK2A3 | |
| SCHEMBL1827959 | 0.79 | LOXL2 (0.54) | KMT2ACSNK2A1ATMCSNK2A2CSNK2B | |
| SCHEMBL6129594 | 0.79 | PLA2G2A (0.56) | ADRA1DKMT2AATMKDM4E | |
| SCHEMBL9202628 | 0.79 | ADRA1D (0.48) | ADRA1DKMT2A | |
| SCHEMBL15729805 | 0.77 | DGAT1 (0.56) | ATMLOXL2 | |
| SCHEMBL6224042 | 0.77 | MKNK1 (0.44) | MKNK1MKNK2KLKB1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101203244-A | Compositions of rennin inhibitor and insulin secernent or insulin sensitizer | NOVARTIS AG (CH) | 2008-06-18 | — | — | CN | claimed |
| CN-101163504-A | Combination therapy | XENON PHARMACEUTICALS INC (CA) | 2008-04-16 | — | — | CN | claimed |
| CN-102600162-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2012-07-25 | — | — | CN | disclosed |
| CN-101980709-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-02-23 | — | — | CN | disclosed |
| CN-101669952-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-03-17 | — | — | CN | disclosed |
| CN-101583365-A | Triazine derivatives and their therapeutical applications | ABRAXIS BIOSCIENCE INC (US) | 2009-11-18 | — | — | CN | disclosed |
| CN-101203244-A | Compositions of rennin inhibitor and insulin secernent or insulin sensitizer | NOVARTIS AG (CH) | 2008-06-18 | — | — | CN | disclosed |
| CN-101163504-A | Combination therapy | XENON PHARMACEUTICALS INC (CA) | 2008-04-16 | — | — | CN | disclosed |