SCHEMBL277747

SCHEMBL277747

Cc1ccc(C)c(-c2ccccc2C)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.52
S1PR4 O95977 2/20 0.47
ALOX15 P16050 3/20 0.45
MEN1 O00255 2/20 0.45
HPGD P15428 2/20 0.45
KMT2A Q03164 2/20 0.45
USP2 O75604 1/20 0.45
MAPT P10636 1/20 0.45
PLA2G7 Q13093 4/20 0.44
LMNA P02545 2/20 0.43
TSHR P16473 1/20 0.43
ACHE P22303 1/20 0.43
TDP1 Q9NUW8 2/20 0.42
CYP2A6 P11509 2/20 0.42
ALDH1A1 P00352 1/20 0.42
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
TP53 P04637 1/20 0.42
GLA P06280 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26968681 0.87 LMNA (0.54) ELANES1PR4MEN1HPGDKMT2A
SCHEMBL197716 0.87 ALDH1A1 (0.52) ELANES1PR4ALOX15MEN1HPGD
SCHEMBL11729295 0.85 ELANE (0.52) ELANEALOX15MEN1HPGDKMT2A
SCHEMBL29590360 0.85 ELANE (0.52) ELANEALOX15MEN1HPGDKMT2A
SCHEMBL732604 0.84 S1PR4 (0.47) ELANES1PR4ALOX15MEN1HPGD
SCHEMBL10385111 0.82 HPGD (0.51) ELANES1PR4ALOX15MEN1HPGD
SCHEMBL852186 0.82 MAOB (0.49) ELANES1PR4ALOX15MEN1HPGD
SCHEMBL7587489 0.82 HDAC7 (0.46) ELANES1PR4MEN1HPGDKMT2A
SCHEMBL851675 0.82 ELANE (0.45) ELANES1PR4ALOX15MEN1HPGD
SCHEMBL15430420 0.82 HPGD (0.59) ELANEALOX15MEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 262 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230127217-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AND ELECTRONIC DEVICE IDEMITSU KOSAN CO.,LTD. (JP) 2023-04-27 US disclosed
US-11247969-B2 Biphenyl compounds useful as muscarinic receptor antagonists THERAVANCE BIOPHARMA R&D IP, LLC (US) 2022-02-15 US disclosed
EP-2797862-B1 OLEFIN OLIGOMERIZATION METHODS CHEVRON PHILLIPS CHEMICAL CO LP (US) 2021-04-07 EP disclosed
US-20210024493-A1 Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity THERAVANCE RESPIRATORY COMPANY, LLC 2021-01-28 US disclosed
US-10836744-B2 Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity THERAVANCE RESPIRATORY COMPANY, LLC (US) 2020-11-17 US disclosed
EP-3507269-B1 STABLE HYDROFORMYLATION CATALYST FOR PREPARATION OF HIGH N/ISO RATIO ALDEHYDE PRODUCT EASTMAN CHEM CO (US) 2020-09-23 EP disclosed
US-20200290966-A1 BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS THERAVANCE BIOPHARMA R&D IP, LLC (US) 2020-09-17 US disclosed
US-20200165223-A1 Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity THERAVANCE RESPIRATORY COMPANY, LLC 2020-05-28 US disclosed
US-10590107-B2 Diamide compounds having muscarinic receptor antagonist and Beta2 adrenergic receptor agonist activity THERAVANCE RESPIRATORY COMPANY, LLC (US) 2020-03-17 US disclosed
US-10570092-B2 Biphenyl compounds useful as muscarinic receptor antagonists THERAVANCE BIOPHARMA R&D IP, LLC (US) 2020-02-25 US disclosed
WO-1995017471-A1 DISAZO COMPOUND ZENECA LIMITED (GB) 1995-06-29 WO disclosed
US-5069991-A NAPHTHOLACTAM OR ISINDOLENINE DYE BASF AKTIENGESELLSCHAFT (DE) 1991-12-03 US disclosed
EP-0289122-B1 UNSATURATED DERIVATIVES OF METHYLENE DIANILINE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-11-27 EP disclosed
US-4922020-A 1,1,5,5-tetra(4-aminophenyl)-pentadi-1,4-ene compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-05-01 US disclosed
US-4906541-A Electrophotographic recording element containing a naphtholactam dye sensitizer BASF AKTIENGESELLSCHAFT (DE) 1990-03-06 US disclosed
EP-0187520-B1 WATER-SOLUBLE DYE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-01-24 EP disclosed
EP-0289122-A1 Unsaturated derivatives of methylene dianiline IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-11-02 EP disclosed
US-4777248-A Water-soluble non-reactive triazinyl mono-azo dye for ink jet printing IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-10-11 US disclosed
US-4726844-A LIGHTFASTNESS CANON KABUSHIKI KAISHA (JP) 1988-02-23 US disclosed
EP-0187520-A2 Water-soluble dye IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-07-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10836744-B2 Diamide compounds having muscarinic receptor antagonist and β2 adrenergic receptor agonist activity ADRB2, ADRB1, ADRA2A ELANE 4700/4885S1PR4 448/4885ALOX15 3826/4885
US-11247969-B2 Biphenyl compounds useful as muscarinic receptor antagonists CHRM2, CHRM1, CHRM3 ELANE 3708/4885S1PR4 632/4885ALOX15 3323/4885
US-20210024493-A1 Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity ADRB2, ADRB1, ADRA2B ELANE 3108/4885S1PR4 372/4885ALOX15 2742/4885
US-10590107-B2 Diamide compounds having muscarinic receptor antagonist and Beta2 adrenergic receptor agonist activity ADRB2, ADRB1, ADRA2B ELANE 4696/4885S1PR4 370/4885ALOX15 3712/4885
US-10570092-B2 Biphenyl compounds useful as muscarinic receptor antagonists CHRM2, CHRM1, CHRM3 ELANE 3708/4885S1PR4 632/4885ALOX15 3323/4885
US-20200290966-A1 BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS CHRM2, CHRM1, CHRM3 ELANE 3708/4885S1PR4 632/4885ALOX15 3323/4885
US-20200165223-A1 Diamide Compounds Having Muscarinic Receptor Antagonist and Beta2 Adrenergic Receptor Agonist Activity ADRB2, ADRB1, ADRA2B ELANE 4696/4885S1PR4 370/4885ALOX15 3712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.