Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.50 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382821 | 0.86 | ADORA2A (0.46) | TLR8TLR7DCPSADORA2AKDM4E | |
| SCHEMBL1008482 | 0.85 | TLR8 (0.46) | TLR8TLR7DCPSADORA2AKDM4E | |
| SCHEMBL7474809 | 0.80 | MAPT (0.44) | TLR8TLR7DCPSADORA2AKDM4E | |
| SCHEMBL11932906 | 0.79 | MDM4 (0.42) | CHRM2ADRA2AADORA3MAOADRD1 | |
| SCHEMBL1451457 | 0.78 | MAOA (0.45) | ADORA2AKDM4EALDH1A1MAOATDP1 | |
| SCHEMBL10169211 | 0.78 | GPR3 (0.57) | TLR8TLR7ADORA2AKDM4EALDH1A1 | |
| SCHEMBL28435353 | 0.76 | NUDT1 (0.49) | ADORA2AKDM4EALDH1A1HPGDADORA3 | |
| SCHEMBL27389038 | 0.74 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTDYRK1ACLK1 | |
| SCHEMBL29583288 | 0.73 | DCPS (0.64) | TLR8TLR7DCPSADORA2AKDM4E | |
| SCHEMBL72801 | 0.73 | DCPS (0.64) | TLR8TLR7DCPSADORA2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528704-B | Serine-threonine protein kinase and PARP modulators | CYLENE PHARMACEUTICALS INC | 2014-04-09 | — | — | CN | disclosed |
| CN-101528704-A | Serine-threonine protein kinase and PARP modulators | CYLENE PHARMACEUTICALS INC (US) | 2009-09-09 | — | — | CN | disclosed |