Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.66 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9148337 | 0.86 | LMNA (0.85) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL10618289 | 0.79 | ALOX15 (0.68) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL3859942 | 0.79 | ALOX15 (1.00) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL11434037 | 0.78 | LMNA (0.66) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL9364002 | 0.78 | ALOX15 (0.71) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL10174797 | 0.78 | CTNNB1 (0.66) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL9821675 | 0.78 | TP53 (0.66) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL1424601 | 0.78 | ALOX15 (0.66) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL30421622 | 0.78 | TP53 (0.66) | LMNAALOX15HPGDSCES2CES1 | |
| SCHEMBL182010 | 0.77 | CES2 (0.71) | LMNAALOX15HPGDSCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101041648-B | Inverse type-1,2-cyclopropane derivative and preparation method thereof | UNIV SHANGHAI | 2010-08-18 | — | — | CN | disclosed |