Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717017 | 0.85 | MEN1 (0.49) | LMNAALOX15CRHBPCRHR2MEN1 | |
| SCHEMBL499847 | 0.81 | MEN1 (0.44) | LMNAALOX15CRHBPCRHR2MEN1 | |
| SCHEMBL14645788 | 0.78 | NPC1 (0.52) | LMNAALOX15CRHBPCRHR2MEN1 | |
| SCHEMBL5967654 | 0.77 | LTA4H (0.50) | LMNAALDH1A1LTA4HMAPTOPRD1 | |
| SCHEMBL27839561 | 0.73 | RIPK1 (0.45) | MEN1KMT2AALDH1A1LTA4HHPGD | |
| SCHEMBL634686 | 0.73 | RIPK1 (0.45) | MEN1KMT2AALDH1A1LTA4HHPGD | |
| SCHEMBL15466212 | 0.73 | ITGA4 (0.57) | LMNAALOX15CRHBPCRHR2MEN1 | |
| SCHEMBL9678516 | 0.73 | CYP1A2 (0.43) | LMNAALOX15CRHBPCRHR2MEN1 | |
| SCHEMBL7697264 | 0.73 | ALDH1A1 (0.50) | LMNAALDH1A1LTA4HMAPTOPRD1 | |
| SCHEMBL6092369 | 0.72 | KDM4E (0.58) | MEN1KMT2AALDH1A1LTA4HHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459246-A | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |