Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125883 | 0.95 | MMP3 (0.66) | MMP3TTRALBCA12CA2 | |
| SCHEMBL321522 | 0.84 | XDH (0.56) | TTRALBPGRXDHSLC22A12 | |
| SCHEMBL178073 | 0.84 | TTR (0.58) | MMP3TTRALBCA12CA2 | |
| SCHEMBL6723587 | 0.82 | TTR (0.63) | MMP3TTRALBCA12CA2 | |
| SCHEMBL19880348 | 0.81 | APP (0.55) | ESR2APP | |
| SCHEMBL2785232 | 0.79 | TTR (0.41) | MMP3TTRALBCYP19A1ESR1 | |
| SCHEMBL21036112 | 0.78 | MMP3 (0.47) | MMP3TTRALBCA12CA2 | |
| SCHEMBL13590994 | 0.77 | ALOX5 (0.62) | MMP3ESR1ESR2APP | |
| SCHEMBL31757686 | 0.77 | KIF11 (0.46) | MMP3TTRALBCA12CA2 | |
| SCHEMBL13368942 | 0.77 | KIF11 (0.46) | MMP3TTRALBCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040054185-A1 | Process for preparing amine-substituted benzofurans | COWART MARLON D (US) | 2004-03-18 | — | — | US | claimed |
| US-20230278956-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-09-07 | — | — | US | disclosed |
| US-11691946-B2 | Preparation of Trifarotene and intermediates and polymorphs thereof | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-07-04 | — | — | US | disclosed |
| US-20230051259-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-02-16 | — | — | US | disclosed |
| US-11254597-B2 | Method for the production of a material of plant origin that is rich in phenolic acids, comprising at least one metal, for carrying out organic synthesis reactions | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-02-22 | — | — | US | disclosed |
| US-11254597-B2 | Method for the production of a material of plant origin that is rich in phenolic acids, comprising at least one metal, for carrying out organic synthesis reactions | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-02-22 | — | — | US | disclosed |
| WO-2021119351-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2021-06-17 | — | — | WO | disclosed |
| US-20200047165-A1 | METHOD FOR THE PRODUCTION OF A MATERIAL OF PLANT ORIGIN THAT IS RICH IN PHENOLIC ACIDS, COMPRISING AT LEAST ONE METAL, FOR CARRYING OUT ORGANIC SYNTHESIS REACTIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-02-13 | — | — | US | disclosed |
| US-20200047165-A1 | METHOD FOR THE PRODUCTION OF A MATERIAL OF PLANT ORIGIN THAT IS RICH IN PHENOLIC ACIDS, COMPRISING AT LEAST ONE METAL, FOR CARRYING OUT ORGANIC SYNTHESIS REACTIONS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-02-13 | — | — | US | disclosed |
| EP-3600661-A1 | METHOD FOR THE PRODUCTION OF A MATERIAL OF PLANT ORIGIN THAT IS RICH IN PHENOLIC ACIDS, COMPRISING AT LEAST ONE METAL, FOR CARRYING OUT ORGANIC SYNTHESIS REACTIONS | Centre National De La Recherche Scientifique (FR) | 2020-02-05 | — | — | EP | disclosed |
| US-20040133007-A1 | Process for preparing amine-substituted benzofurans | ABBOTT LABORATORIES | 2004-07-08 | — | — | US | disclosed |
| WO-2004024707-A2 | PROCESS FOR PREPARING AMINE TYPE SUBSTITUTED BENZOFURANS | ABBOTT LABORATORIES (US) | 2004-03-25 | — | — | WO | disclosed |
| US-20040054185-A1 | Process for preparing amine-substituted benzofurans | COWART MARLON D (US) | 2004-03-18 | — | — | US | disclosed |
| US-6620839-B2 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | ABBOTT LABORATORIES | 2003-09-16 | — | — | US | disclosed |
| US-20030153548-A1 | Histamine-3 receptor ligands for diabetic conditions | ABBOTT LABORATORIES | 2003-08-14 | — | — | US | disclosed |
| US-20030134835-A1 | Histamine-3 receptor ligands for diabetes conditions | ABBOTT LABORATORIES | 2003-07-17 | — | — | US | disclosed |
| US-20020183309-A1 | Novel amines as histamine-3 receptor ligands and their therapeutic applications | ABBOTT LABORATORIES | 2002-12-05 | — | — | US | disclosed |
| US-20020177589-A1 | Novel amines as histamine-3 receptor ligands and their therapeutic applications | ABBOTT LABORATORIES | 2002-11-28 | — | — | US | disclosed |
| US-20020169188-A1 | Novel amines as histamine-3 receptor ligands and their therapeutic applications | ABBVIE INC. | 2002-11-14 | — | — | US | disclosed |
| US-20020137931-A1 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | ABBVIE INC. | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137931-A1 | 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications | HRH3, HRH4, HRH1 | MMP3 2210/4885TTR 4651/4885ALB 3166/4885 |
| US-20230051259-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | UGT1A4, TBK1, UGT1A7 | MMP3 4655/4885TTR 2239/4885ALB 4657/4885 |
| US-20230278956-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | UGT1A4, TBK1, UGT1A7 | MMP3 4655/4885TTR 2239/4885ALB 4657/4885 |
| US-20020177589-A1 | Novel amines as histamine-3 receptor ligands and their therapeutic applications | HRH3, HRH4, HRH1 | MMP3 3450/4885TTR 4468/4885ALB 3852/4885 |
| US-11691946-B2 | Preparation of Trifarotene and intermediates and polymorphs thereof | UGT1A4, TBK1, UGT1A7 | MMP3 4655/4885TTR 2239/4885ALB 4657/4885 |
| US-20040133007-A1 | Process for preparing amine-substituted benzofurans | HRH4, HRH2, HRH3 | MMP3 3684/4885TTR 4874/4885ALB 4169/4885 |
| US-20020169188-A1 | Novel amines as histamine-3 receptor ligands and their therapeutic applications | HRH3, HRH4, HRH1 | MMP3 3450/4885TTR 4468/4885ALB 3852/4885 |
| US-20200047165-A1 | METHOD FOR THE PRODUCTION OF A MATERIAL OF PLANT ORIGIN THAT IS RICH IN PHENOLIC ACIDS, COMPRISING AT LEAST ONE METAL, FOR CARRYING OUT ORGANIC SYNTHESIS REACTIONS | COMT, VARS1, CROCC | MMP3 3050/4885TTR 1044/4885ALB 37/4885 |
| US-20030153548-A1 | Histamine-3 receptor ligands for diabetic conditions | HRH4, HRH2, HRH3 | MMP3 1969/4885TTR 4387/4885ALB 2598/4885 |
| US-20020183309-A1 | Novel amines as histamine-3 receptor ligands and their therapeutic applications | HRH3, HRH4, HRH1 | MMP3 3450/4885TTR 4468/4885ALB 3852/4885 |
| US-20030134835-A1 | Histamine-3 receptor ligands for diabetes conditions | HRH4, HRH2, HRH3 | MMP3 2114/4885TTR 4225/4885ALB 2447/4885 |
| US-20040054185-A1 | Process for preparing amine-substituted benzofurans | HRH4, HRH2, HRH3 | MMP3 3684/4885TTR 4874/4885ALB 4169/4885 |
| US-11254597-B2 | Method for the production of a material of plant origin that is rich in phenolic acids, comprising at least one metal, for carrying out organic synthesis reactions | COMT, VARS1, CROCC | MMP3 3050/4885TTR 1044/4885ALB 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.