Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 2/20 | 0.49 |
| ▸ | KLK1 | P06870 | 2/20 | 0.49 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.49 |
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | TERT | O14746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17538569 | 0.84 | ALDH1A1 (0.63) | AURKBPLGKLK1KLK6CFD | |
| SCHEMBL27484183 | 0.84 | FADS1 (0.60) | AURKBPLGKLK1KLK6CFD | |
| SCHEMBL23367948 | 0.83 | SMN1; SMN2 (0.68) | AURKBALDH1A1SMN1; SMN2 | |
| SCHEMBL27795055 | 0.82 | PLG (0.60) | AURKBPLGKLK1KLK6 | |
| SCHEMBL6681834 | 0.79 | KCNK3 (0.69) | CFD | |
| SCHEMBL94334 | 0.78 | ALDH1A1 (0.66) | ALDH1A1 | |
| SCHEMBL2304215 | 0.78 | MEN1 (0.70) | ALDH1A1 | |
| SCHEMBL2308674 | 0.78 | FADS1 (0.70) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL28135448 | 0.77 | KCNMA1 (0.41) | PLGKLK1KLK6CFDKLKB1 | |
| SCHEMBL17976484 | 0.75 | CFD (0.60) | CFDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664973-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2014-03-26 | — | — | CN | claimed |
| CN-106928247-A | Spiral shell oxindole compounds and its purposes as therapeutic agent | 泽农医药公司 | 2017-07-07 | — | — | CN | disclosed |
| CN-103664973-B | Spiro-oxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-102256983-B | Spirooxindole compounds and their use as therapeutic agents | 泽农医药公司 | 2017-04-05 | — | — | CN | disclosed |
| CN-103664973-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2014-03-26 | — | — | CN | disclosed |