Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Thiouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.32 |
| ▸ | LPO | P22079 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiouracil SCHEMBL9172 | 0.87 | — | — | |
| Thiouracil SCHEMBL546068 | 0.87 | — | — | |
| Thiouracil SCHEMBL27922231 | 0.85 | — | — | |
| Thiouracil SCHEMBL30091289 | 0.85 | — | — | |
| Thiouracil SCHEMBL28095966 | 0.80 | TP53 (0.76) | TP53CRBNMMP2BAZ2BCYP2C19 | |
| Uracil SCHEMBL28120281 | 0.79 | TP53 (0.83) | TP53CRBNMMP2BAZ2BCYP2C19 | |
| Uracil SCHEMBL9145913 | 0.79 | CRBN (0.74) | TP53CRBNMMP2F2 | |
| Thiouracil SCHEMBL7804101 | 0.78 | TP53 (0.79) | TP53CRBNMMP2BAZ2BCYP2C19 | |
| Thiouracil SCHEMBL18815516 | 0.76 | TP53 (0.76) | TP53CRBNMMP2BAZ2BLPO | |
| Thiouracil SCHEMBL28205719 | 0.74 | TP53 (0.73) | TP53CRBNMMP2BAZ2BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917529-B | 2-Thiopyrimidinones | 辉瑞大药厂 | 2016-08-17 | — | — | CN | disclosed |
| CN-103917529-A | 2-thiopyrimidinones | PFIZER | 2014-07-09 | — | — | CN | disclosed |