Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | LPO | P22079 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | TAS2R38 | P59533 | 2/20 | 0.39 |
| ▸ | TPO | P07202 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYB5R3 | P00387 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiouracil SCHEMBL9172 | 0.87 | — | — | |
| Thiouracil SCHEMBL27922231 | 0.85 | — | — | |
| Thiouracil SCHEMBL30091289 | 0.85 | — | — | |
| Thiouracil SCHEMBL27970384 | 0.80 | TP53 (0.76) | TP53CRBNLPOCYP2C19TAS2R38 | |
| Uracil SCHEMBL28120281 | 0.79 | TP53 (0.83) | TP53CRBNLPOCYP2C19TAS2R38 | |
| Thiouracil SCHEMBL28205719 | 0.78 | TP53 (0.73) | TP53CRBNLPOCYP2C19MPO | |
| Thiouracil SCHEMBL7804101 | 0.78 | TP53 (0.79) | TP53CRBNLPOCYP2C19TAS2R38 | |
| Thiouracil SCHEMBL28203909 | 0.74 | TP53 (0.54) | TP53CRBNLPOCYP2C19MPO | |
| Thiouracil SCHEMBL4958659 | 0.74 | TP53 (0.66) | TP53CRBNLPOMMP2SMN1; SMN2 | |
| Thiouracil SCHEMBL8613383 | 0.73 | TP53 (0.70) | TP53CRBNLPOCYP2C19MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103347864-B | Pyrimidone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA 2 | 葛兰素集团有限公司 | 2016-08-10 | — | — | CN | disclosed |