Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Thiouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | LPO | P22079 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | TAS2R38 | P59533 | 2/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | TPO | P07202 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiouracil SCHEMBL9172 | 0.85 | — | — | |
| Thiouracil SCHEMBL30091289 | 0.83 | — | — | |
| Thiouracil SCHEMBL27922231 | 0.83 | — | — | |
| Uracil SCHEMBL29005629 | 0.80 | CRBN (0.71) | TP53CRBNMMP2 | |
| Thiouracil SCHEMBL28095966 | 0.78 | TP53 (0.76) | TP53CRBNMMP2LPOPTGS1 | |
| Uracil SCHEMBL28120281 | 0.78 | TP53 (0.83) | TP53CRBNMMP2LPOPTGS1 | |
| Thiouracil SCHEMBL7804101 | 0.76 | TP53 (0.79) | TP53CRBNMMP2LPOPTGS1 | |
| Thiouracil SCHEMBL27970384 | 0.74 | TP53 (0.76) | TP53CRBNMMP2LPOPTGS1 | |
| Thiouracil SCHEMBL4958659 | 0.73 | TP53 (0.66) | TP53CRBNMMP2LPOPTGS1 | |
| Thiouracil SCHEMBL8613383 | 0.72 | TP53 (0.70) | TP53CRBNMMP2LPOPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107778254-A | The synthetic method of the pyrimidine derivatives of Internmediate of anti viral medicine oxo two | 陈国妃 | 2018-03-09 | — | — | CN | disclosed |