Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487951 | 0.83 | LMNA (0.43) | KDM4EMAPTPOLBL3MBTL1TDP1 | |
| SCHEMBL157144 | 0.79 | TSHR (0.37) | KDM4EPTGS2POLBCA12CA1 | |
| Ethylenediamine SCHEMBL731611 | 0.77 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL2799841 | 0.74 | ALDH1A1 (0.44) | KDM4EMAPTPOLBGAAPTGS1 | |
| SCHEMBL19362158 | 0.72 | POLB (0.34) | KDM4EPTGS2POLBGAAPTGS1 | |
| SCHEMBL6580109 | 0.71 | PTPN9 (0.34) | KDM4EPTGS2POLBPTGS1TDP1 | |
| SCHEMBL10465166 | 0.69 | TAAR1 (0.40) | KDM4EMAPTPOLBL3MBTL1GAA | |
| SCHEMBL29120261 | 0.68 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| Ethylenediamine SCHEMBL14353963 | 0.68 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL30720426 | 0.68 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10925814-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-02-23 | — | — | US | disclosed |
| US-10813860-B2 | Leave-in chemical foam comprising benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-10-27 | — | — | US | disclosed |
| US-10702466-B2 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-07-07 | — | — | US | disclosed |
| US-10449175-B2 | Rinse-off chemical mousse containing benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-10-22 | — | — | US | disclosed |
| EP-2175935-B1 | TOPICAL COMPOSITION CONTAINING ADAPALENE FOR THE TREATMENT OF KERATINIZATION DISORDERS | GALDERMA RES & DEV (FR) | 2018-10-24 | — | — | EP | disclosed |
| US-20180263865-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-09-20 | — | — | US | disclosed |
| US-20180185283-A1 | NON-RINSE CHEMICAL MOUSSE CONTAINING ADAPALENE AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-07-05 | — | — | US | disclosed |
| US-9999577-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-06-19 | — | — | US | disclosed |
| US-20170172972-A1 | RINSE-OFF CHEMICAL MOUSSE CONTAINING BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-06-22 | — | — | US | disclosed |
| US-20170172877-A1 | LEAVE-IN CHEMICAL FOAM COMPRISING BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-06-22 | — | — | US | disclosed |
| US-20150098918-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-04-09 | — | — | US | disclosed |
| US-8957112-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-02-17 | — | — | US | disclosed |
| US-8716341-B2 | Topically applicable compositions for the treatment of keratinization disorders | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-05-06 | — | — | US | disclosed |
| US-20100166852-A1 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-01 | — | — | US | disclosed |
| US-20100144883-A1 | TOPICALLY APPLICABLE COMPOSITIONS FOR THE TREATMENT OF KERATINIZATION DISORDERS | GALDERMA RESEARCH & DEVELOPMENT, BIOT, FRANCE | 2010-06-10 | — | — | US | disclosed |
| US-20090318550-A1 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-12-24 | — | — | US | disclosed |
| US-20090191245-A1 | REDUCED-IRRITANT DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID COMPOUND AND BENZOYL PEROXIDE AND TREATMENT OF KERATINIZATION DISORDERS THEREWITH | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-07-30 | — | — | US | disclosed |
| US-20090098219-A1 | Cosmetic/pharmaceutical compositions comprising retinoids and anti-irritants and treatment of keratinization disorders therewith | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-04-16 | — | — | US | disclosed |
| US-20090012172-A1 | Cosmetic/pharmaceutical compositions comprising retinoids and anti-irritants and treatment of keratinization disorders therewith | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090191245-A1 | REDUCED-IRRITANT DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID COMPOUND AND BENZOYL PEROXIDE AND TREATMENT OF KERATINIZATION DISORDERS THEREWITH | CUTA, KRT18, RARA | KDM4E 4350/4885MAPT 3554/4885PTGS2 784/4885 |
| US-20100144883-A1 | TOPICALLY APPLICABLE COMPOSITIONS FOR THE TREATMENT OF KERATINIZATION DISORDERS | KRT18, COL14A1, ADCY10 | KDM4E 2849/4885MAPT 2801/4885PTGS2 2731/4885 |
| US-20090012172-A1 | Cosmetic/pharmaceutical compositions comprising retinoids and anti-irritants and treatment of keratinization disorders therewith | KRT18, RARA, RARB | KDM4E 2825/4885MAPT 3338/4885PTGS2 1497/4885 |
| US-20090098219-A1 | Cosmetic/pharmaceutical compositions comprising retinoids and anti-irritants and treatment of keratinization disorders therewith | RARA, RARB, RARG | KDM4E 3512/4885MAPT 3994/4885PTGS2 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.