Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA6 | P23280 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM5A | P29375 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL14353963 | 0.87 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| Ethylenediamine SCHEMBL8671797 | 0.81 | KDM4E (0.46) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL2797912 | 0.77 | KDM4E (0.42) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| Ethylenediamine SCHEMBL544736 | 0.75 | TSHR (0.42) | KDM4EMAPTPTGS2POLBCA12 | |
| Ethylenediamine SCHEMBL5159417 | 0.74 | TSHR (0.41) | KDM4EMAPTPTGS2POLBCA12 | |
| SCHEMBL30720426 | 0.73 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL29120261 | 0.73 | KDM4E (0.48) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL383610 | 0.73 | HSP90AA1 (0.60) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL1446646 | 0.72 | RORC (0.53) | KDM4EMAPTPTGS2POLBL3MBTL1 | |
| SCHEMBL2797924 | 0.72 | KDM4E (0.47) | KDM4EMAPTPTGS2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191431-B1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORP (US) | 2023-03-08 | — | — | EP | claimed |
| US-20170283334-A1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORPORATION (US) | 2017-10-05 | — | — | US | claimed |
| EP-3191431-A1 | MICRONUTRIENT FERTILIZER | Sun Chemical Corporation (US) | 2017-07-19 | — | — | EP | claimed |
| WO-2016040564-A1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORPORATION (US) | 2016-03-17 | — | — | WO | claimed |
| EP-3191431-B1 | MICRONUTRIENT FERTILIZER | SUN CHEMICAL CORP (US) | 2023-03-08 | — | — | EP | disclosed |
| US-11234931-B2 | No-rinse chemical foam containing brimonidine, and use thereof in the treatment of rosacea | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2022-02-01 | — | — | US | disclosed |
| US-11160812-B2 | No-rinse chemical foam containing clobetasol propionate, and use thereof in the treatment of psoriasis | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-11-02 | — | — | US | disclosed |
| US-11020348-B2 | No-rinse chemical foam containing trifarotene, and use thereof in the treatment of ichthyosis | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-06-01 | — | — | US | disclosed |
| US-11020347-B2 | No-rinse chemical foam containing trifarotene, and use thereof in the treatment of acne | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-06-01 | — | — | US | disclosed |
| US-10987307-B2 | No-rinse chemical foam comprising ivermectin | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-04-27 | — | — | US | disclosed |
| US-10821076-B2 | Self-foaming cleansing composition containing clobetasol propionate, and use thereof in the treatment of psoriasis | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-11-03 | — | — | US | disclosed |
| US-10407353-B2 | Micronutrient fertilizer | SUN CHEMICAL CORPORATION (US) | 2019-09-10 | — | — | US | disclosed |
| US-20100160439-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-06-24 | — | — | US | disclosed |
| US-20100143285-A1 | Dermatological/pharmaceutical compositions comprising benzoyl peroxide, at least one naphthoic acid compound and at least one polyurethane polymer | GALDERMA RESEARCH & DEVELOPMENT, BIOT, FRANCE. | 2010-06-10 | — | — | US | disclosed |
| EP-2167063-A1 | COMPOSITION AND USES OF A RETINOID, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE, IN ACNE | Galderma Research & Development (FR) | 2010-03-31 | — | — | EP | disclosed |
| EP-2167062-A1 | COMPOSITIONS AND USES COMPRISING A RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE IN ACNE | Galderma Research & Development (FR) | 2010-03-31 | — | — | EP | disclosed |
| US-20090247630-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID COMPOUND AND AT LEAST ONE FILM-FORMING AGENT AND TREATMENT OF KERATINIZATION DISORDERS THEREWITH | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-10-01 | — | — | US | disclosed |
| WO-2008152064-A1 | COMPOSITIONS AND USES COMPRISING A RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE IN ACNE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152065-A1 | COMPOSITION AND USES OF A RETINOID, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE, IN ACNE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-12-18 | — | — | WO | disclosed |
| US-20080253986-A1 | Cosmetic/dermatological compositions comprising naphthoic acid compounds and polyurethane polymers | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11160812-B2 | No-rinse chemical foam containing clobetasol propionate, and use thereof in the treatment of psoriasis | PRKACA, NOS1, NOS2 | KDM4E 2490/4885MAPT 3765/4885PTGS2 389/4885 |
| US-20090247630-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID COMPOUND AND AT LEAST ONE FILM-FORMING AGENT AND TREATMENT OF KERATINIZATION DISORDERS THEREWITH | CUTA, NOTUM, KRT18 | KDM4E 4333/4885MAPT 989/4885PTGS2 2319/4885 |
| US-20080253986-A1 | Cosmetic/dermatological compositions comprising naphthoic acid compounds and polyurethane polymers | CUTA, NACA, PUF60 | KDM4E 4695/4885MAPT 534/4885PTGS2 1519/4885 |
| US-20100143285-A1 | Dermatological/pharmaceutical compositions comprising benzoyl peroxide, at least one naphthoic acid compound and at least one polyurethane polymer | CUTA, PAOX, HAO2 | KDM4E 3878/4885MAPT 406/4885PTGS2 752/4885 |
| US-11234931-B2 | No-rinse chemical foam containing brimonidine, and use thereof in the treatment of rosacea | NOS1, NOS2, PDE2A | KDM4E 3364/4885MAPT 4734/4885PTGS2 419/4885 |
| US-20100160439-A1 | DERMATOLOGICAL COMPOSITIONS COMPRISING AT LEAST ONE RETINOID COMPOUND, AN ANTI-IRRITANT COMPOUND AND BENZOYL PEROXIDE | RARB, RARA, RARG | KDM4E 4729/4885MAPT 3304/4885PTGS2 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.