Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
| ▸ | RARB | P10826 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28065629 | 0.86 | FPR2 (0.33) | DHODH | |
| SCHEMBL28014013 | 0.86 | MAPK1 (0.35) | MAPK1SLC6A2SLC6A3NPC1RAB9A | |
| SCHEMBL28026523 | 0.86 | BCL2L1 (0.39) | ALDH1A1CCR2RARARARBRARG | |
| SCHEMBL28853365 | 0.86 | ALPL (0.31) | MAPTTHRBTDP1 | |
| SCHEMBL27332909 | 0.86 | HPGDS (0.38) | DHODHRARARARBRARG | |
| SCHEMBL28099170 | 0.84 | CA1 (0.40) | NPC1RAB9AMAPTALDH1A1TDP1 | |
| SCHEMBL27330148 | 0.84 | MCL1 (0.40) | MAPTSMN1; SMN2ALDH1A1RARARARB | |
| SCHEMBL28093777 | 0.84 | SLC6A3 (0.40) | SLC6A2SLC6A3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28841114 | 0.83 | CES2 (0.33) | — | |
| SCHEMBL28069748 | 0.83 | CA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107235867-A | It is used as the aryl sultam derivative of RORc conditioning agents | 弗·哈夫曼-拉罗切有限公司 | 2017-10-10 | — | — | CN | claimed |
| CN-104470917-B | Aryl sultam derivatives as RORc modulators | 弗·哈夫曼-拉罗切有限公司 | 2017-08-04 | — | — | CN | claimed |
| CN-104470917-A | Aryl sultam derivatives as RORc modulators | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | claimed |