SCHEMBL28014126

SCHEMBL28014126

FB(F)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TRPV6 Q9H1D0 2/20 0.61
ORAI1 Q96D31 1/20 0.61
ORAI2 Q96SN7 1/20 0.61
ORAI3 Q9BRQ5 1/20 0.61
MGLL Q99685 1/20 0.61
ALDH1A1 P00352 1/20 0.46
TSHR P16473 1/20 0.46
KIF11 P52732 6/20 0.44
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
TAAR1 Q96RJ0 1/20 0.39
EPHX2 P34913 1/20 0.38
HTR3E A5X5Y0 1/20 0.38
HTR3B O95264 1/20 0.38
PLAU P00749 1/20 0.38
HTR3A P46098 1/20 0.38
HTR3D Q70Z44 1/20 0.38
HTR3C Q8WXA8 1/20 0.38
IDO1 P14902 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ether SCHEMBL28014124 0.83 TRPV6 (0.45) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL813859 0.80 TRPV6 (0.64) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL8052154 0.78 ORAI1 (0.35) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL63468 0.78 ALDH1A1 (0.67) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL15402212 0.76 TRPV6 (0.58) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL4179 0.76 MGLL (1.00) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL2406706 0.76 TRPV6 (1.00) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL1493140 0.72 CES2 (0.42) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL14477120 0.72 TRPV6 (0.67) TRPV6ORAI1ORAI2ORAI3MGLL
SCHEMBL7631823 0.72 TRPV6 (0.69) TRPV6ORAI1ORAI2ORAI3MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104610329-A Diboron nitride bridge-linked bipyridine and organic/ high polymer material prepared from diboron nitride bridge-linked bipyridine CHANGCHUN APPLIED CHEMISTRY 2015-05-13 CN disclosed