Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25278077 | 0.82 | MAPT (0.58) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL25275004 | 0.82 | L3MBTL1 (0.58) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL1952636 | 0.81 | ALOX5 (0.47) | GAAMAPTJAK2LMNA | |
| SCHEMBL13724306 | 0.81 | KDM4E (0.56) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL27938524 | 0.81 | FAAH (0.59) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL25463196 | 0.81 | GAA (0.60) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL92889 | 0.79 | ALDH1A1 (0.61) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL28964300 | 0.79 | GAA (0.43) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL11463950 | 0.78 | CES2 (0.60) | GAAMAPTPOLBKMT2AKDM4E | |
| SCHEMBL9813619 | 0.78 | ALDH1A1 (0.69) | GAAMAPTPOLBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104744456-A | Benzoquinolone inhibitors of VMAT2 | AUSPEX PHARMACEUTICAL INC | 2015-07-01 | — | — | CN | disclosed |