Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30252481 | 1.00 | P2RX7 (0.59) | P2RX7ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL14094489 | 0.82 | BAZ2B (0.43) | P2RX7GAAPOLB | |
| SCHEMBL14094492 | 0.81 | GABRA1 (0.46) | P2RX7ALDH1A1GAAKDM4ECYP1A2 | |
| SCHEMBL31589339 | 0.77 | NNMT (0.65) | P2RX7ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL18896184 | 0.77 | GABRA1 (0.46) | ALDH1A1MAPTKDM4E | |
| SCHEMBL16454215 | 0.77 | GABRA1 (0.46) | P2RX7ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL2469953 | 0.77 | NNMT (0.59) | P2RX7KMT2APOLBADORA3NNMT | |
| SCHEMBL17298866 | 0.77 | CNR2 (0.40) | P2RX7 | |
| SCHEMBL8600253 | 0.76 | P2RX7 (0.52) | P2RX7ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL31306809 | 0.76 | P2RX7 (0.52) | P2RX7ALDH1A1GAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126869-B1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS | HOFFMANN LA ROCHE (CH) | 2024-06-05 | — | — | EP | disclosed |
| US-20240002393-A1 | SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS | HOFFMANN-LA ROCHE INC. (US) | 2024-01-04 | — | — | US | disclosed |
| US-11739095-B2 | Substituted benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepines as GABA A GAMMA1 positive allosteric modulators | HOFFMANN-LA ROCHE INC. (US) | 2023-08-29 | — | — | US | disclosed |
| EP-4126869-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS | F. Hoffmann-La Roche AG (CH) | 2023-02-08 | — | — | EP | disclosed |
| CN-115380034-A | Benzodiazepine derivatives as GABA a γ 1 PAM | 豪夫迈·罗氏有限公司 | 2022-11-22 | — | — | CN | disclosed |
| US-20210309664-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | HOFFMANN-LA ROCHE INC. (US) | 2021-10-07 | — | — | US | disclosed |
| WO-2021198124-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS | F. HOFFMANN-LA ROCHE AG (CH) | 2021-10-07 | — | — | WO | disclosed |
| US-8134013-B2 | Amide compound and thrombopoietin receptor activator | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-03-13 | — | — | US | disclosed |
| US-8134013-B2 | Amide compound and thrombopoietin receptor activator | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-03-13 | — | — | US | disclosed |
| US-20090131659-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
| US-20090131659-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
| EP-1845090-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | Nissan Chemical Industries, Ltd. (JP) | 2007-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309664-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | GABRA1, GABRB1, GABRG1 | P2RX7 334/4885ALDH1A1 522/4885GAA 1478/4885 |
| US-20090131659-A1 | AMIDE COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | TEK, PTAFR, MPL | P2RX7 744/4885ALDH1A1 2047/4885GAA 2220/4885 |
| US-11739095-B2 | Substituted benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepines as GABA A GAMMA1 positive allosteric modulators | GABRA1, GABRB1, GABRG1 | P2RX7 471/4885ALDH1A1 825/4885GAA 2696/4885 |
| US-20240002393-A1 | SUBSTITUTED BENZO[f][l ,2,4JTRIAZOL0[4,3-a][l ,4JDIAZEPINES AS GABA A GAMMA! POSITIVE ALLOSTERIC MODULATORS | GABRA4, GABRB1, GABRB3 | P2RX7 514/4885ALDH1A1 847/4885GAA 2444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.