Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264980 | 0.94 | — | — | |
| Isopropyl Alcohol SCHEMBL9624545 | 0.82 | MAPK1 (0.40) | TSHRTDP1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL27990721 | 0.80 | CYP2D6 (0.32) | — | |
| SCHEMBL5708413 | 0.77 | — | — | |
| SCHEMBL11296882 | 0.77 | — | — | |
| SCHEMBL3837098 | 0.77 | — | — | |
| SCHEMBL6177314 | 0.76 | TSHR (0.40) | TSHRTDP1ALDH1A1 | |
| SCHEMBL1114762 | 0.75 | MMP8 (0.34) | — | |
| SCHEMBL14523519 | 0.73 | TSHR (0.38) | TSHRTDP1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28290535 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108148394-A | The stable mono-component polyurethane prepreg of storage from urethane composition and thus obtained formed body | 赢创德固赛有限公司 | 2018-06-12 | — | — | CN | claimed |
| CN-103459452-B | Storage-stable polyurethane prepregs made of polyurethane compositions with liquid resin components and molded parts made therefrom | EVONIK DEGUSSA GMBH (DE) | 2016-11-30 | — | — | CN | claimed |
| CN-108148394-A | The stable mono-component polyurethane prepreg of storage from urethane composition and thus obtained formed body | 赢创德固赛有限公司 | 2018-06-12 | — | — | CN | disclosed |
| CN-107540807-A | Functionalized with alkoxysilane, coating agent containing allophanate | 赢创德固赛有限公司 | 2018-01-05 | — | — | CN | disclosed |
| CN-103459452-B | Storage-stable polyurethane prepregs made of polyurethane compositions with liquid resin components and molded parts made therefrom | EVONIK DEGUSSA GMBH (DE) | 2016-11-30 | — | — | CN | disclosed |
| CN-103210011-B | The method manufacturing the polyurethane-prepreg of stable storing and the profiled member of the urethane composition derived from solution being made from | 赢创德固赛有限公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-105082707-A | Production of fibre composite component part based on aluminium and polyurethane | EVONIK INDUSTRIES AG | 2015-11-25 | — | — | CN | disclosed |
| CN-105082665-A | PRODUCTION OF FIBRE COMPOSITE COMPONENT PART BASED ON STEEL AND POLYURETHANE | EVONIK INDUSTRIES AG | 2015-11-25 | — | — | CN | disclosed |
| CN-102906140-B | The method manufacturing the urethane-prepreg of stable storing and the profiled member be made up of it | EVONIK DEGUSSA GMBH (DE) | 2015-11-25 | — | — | CN | disclosed |