Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28058576 | 0.82 | MEN1 (0.40) | MAPK1TSHRKMT2AHIF1ABLM | |
| Hydrochloric Acid SCHEMBL7195502 | 0.76 | GPR3 (0.41) | MAPK1TSHRKMT2ABLM | |
| SCHEMBL9770501 | 0.73 | NR1H2 (0.46) | CYP2C19CYP1A2MAPK1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL28058646 | 0.73 | NR3C1 (0.39) | CYP2C19CYP1A2TSHRNR3C1CYP2D6 | |
| Hydrochloric Acid SCHEMBL7191899 | 0.73 | GPR3 (0.34) | CYP2C19CYP1A2MAPK1TSHRCYP2D6 | |
| Hydrochloric Acid SCHEMBL540484 | 0.71 | GPR3 (0.44) | CYP1A2CYP2D6HTR1AADRA2AADRA1A | |
| SCHEMBL2960872 | 0.69 | CYP2C19 (0.78) | CYP2C19CYP1A2NR1H2NR1H3CRHBP | |
| Hydrochloric Acid SCHEMBL7944464 | 0.69 | GPR3 (0.42) | CYP1A2CYP2D6HTR1AADRA2AADRA1A | |
| SCHEMBL20370919 | 0.68 | CYP2C19 (0.50) | CYP2C19CYP1A2MAPK1NR1H2NR1H3 | |
| SCHEMBL10974928 | 0.67 | CRHBP (0.68) | CYP2C19CYP1A2NR1H2NR1H3CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106133042-B | Ultrahigh molecular weight polyethylene stretches microporous membrane | 东曹株式会社 | 2019-11-26 | — | — | CN | disclosed |
| CN-105377909-B | Ultra high molecular weight polyethylene particles and the formed body formed by it | 东曹株式会社 | 2018-04-03 | — | — | CN | disclosed |
| CN-106133042-A | Ultrahigh molecular weight polyethylene stretching micro-porous film | 东曹株式会社 | 2016-11-16 | — | — | CN | disclosed |
| CN-105377909-A | Ultra-high-molecular-weight polyethylene particles and molded body comprising same | TOSOH CORP | 2016-03-02 | — | — | CN | disclosed |