Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28058584 | 0.82 | DDB1 (0.38) | KDM4E | |
| Hydrochloric Acid SCHEMBL7192917 | 0.76 | MAPT (0.46) | TSHRKDM4ELMNANPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28058663 | 0.73 | CYP2C19 (0.42) | NR3C1TSHRCYP2C19LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL7192401 | 0.73 | MAPT (0.36) | KDM4ELMNAALDH1A1MAPT | |
| SCHEMBL8931022 | 0.69 | PABPC1 (0.62) | NR3C1PGRNR3C2ARKDM4E | |
| SCHEMBL7148219 | 0.69 | TSHR (0.54) | NR3C1PGRNR3C2ARTSHR | |
| SCHEMBL28110311 | 0.68 | NR3C1 (0.42) | NR3C1PGRNR3C2ARCRHR1 | |
| Hydrochloric Acid SCHEMBL7251524 | 0.67 | MYC (0.38) | TSHRKDM4ELMNANPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL540484 | 0.67 | GPR3 (0.44) | CYP1A2POLBCYP2D6 | |
| Hydrochloric Acid SCHEMBL8918026 | 0.66 | PDE10A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106133042-B | Ultrahigh molecular weight polyethylene stretches microporous membrane | 东曹株式会社 | 2019-11-26 | — | — | CN | disclosed |
| CN-105377909-B | Ultra high molecular weight polyethylene particles and the formed body formed by it | 东曹株式会社 | 2018-04-03 | — | — | CN | disclosed |
| CN-106133042-A | Ultrahigh molecular weight polyethylene stretching micro-porous film | 东曹株式会社 | 2016-11-16 | — | — | CN | disclosed |
| CN-105377909-A | Ultra-high-molecular-weight polyethylene particles and molded body comprising same | TOSOH CORP | 2016-03-02 | — | — | CN | disclosed |