Water

Water

SCHEMBL28060834

CO[Si](C)(CCCO)OC.O

nearest known ligand 0.30

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2156398 0.97 ALDH1A1 (0.32) ALDH1A1
Ammonia Solution, Strong SCHEMBL27991089 0.95 ALDH1A1 (0.30) ALDH1A1
SCHEMBL28106994 0.95 ALDH1A1 (0.30) ALDH1A1
Phosphine SCHEMBL28031041 0.95 ALDH1A1 (0.30) ALDH1A1
Propanol SCHEMBL28326995 0.93 ALDH1A1 (0.38) ALDH1A1
SCHEMBL28032369 0.93
Alcohol SCHEMBL28056034 0.92 ALDH1A1 (0.35) ALDH1A1
Cyanate SCHEMBL28112345 0.91
SCHEMBL28275235 0.90
SCHEMBL28699233 0.90 SMN1; SMN2 (0.35) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107012456-A Metal surface pretreating reagent that a kind of alkoxyl silicone ethyl Polyhedral Oligomeric silsesquioxane is modified and preparation method thereof, application 武汉大学 2017-08-04 CN claimed
CN-107849232-A Use of alcohols containing at least two urethane groups for producing polyether carbonate polyols 科思创德国股份有限公司 2018-03-27 CN disclosed
CN-107541177-A The preparation method of silane work(graphene, antistatic silicone pressure sensitive adhesive and preparation method thereof 深圳市康利邦科技有限公司 2018-01-05 CN disclosed
CN-107012456-A Metal surface pretreating reagent that a kind of alkoxyl silicone ethyl Polyhedral Oligomeric silsesquioxane is modified and preparation method thereof, application 武汉大学 2017-08-04 CN disclosed
CN-106519938-A Coating composite 关西涂料株式会社 2017-03-22 CN disclosed
CN-106189878-A Peelable adhesive composition and peelable adhesive tape 奇美实业股份有限公司 2016-12-07 CN disclosed
CN-106054546-A Toner 佳能株式会社 2016-10-26 CN disclosed
CN-102827389-B The manufacture method of eyeglass 埃西勒国际通用光学公司 2016-08-17 CN disclosed