Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070925 | 0.81 | — | — | |
| SCHEMBL7945628 | 0.71 | ACE (0.38) | IDO1 | |
| SCHEMBL28292382 | 0.69 | IDO1 (0.43) | IDO1 | |
| SCHEMBL8699123 | 0.68 | ALDH1A1 (0.37) | PRMT5 | |
| Ethoxycarbonyl Group SCHEMBL28071030 | 0.68 | DRD3 (0.36) | IDO1 | |
| SCHEMBL4666509 | 0.67 | IDO1 (0.41) | IDO1 | |
| SCHEMBL28295597 | 0.67 | PNMT (0.37) | IDO1 | |
| SCHEMBL27497694 | 0.67 | IDO1 (0.58) | IDO1 | |
| SCHEMBL9865740 | 0.66 | KDM4E (0.50) | CYP1A2CYP2D6CYP2C9CYP2C19NPC1 | |
| SCHEMBL24890476 | 0.64 | IDO1 (0.43) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105793266-B | Spiro-oxazolones | 豪夫迈·罗氏有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-105814062-A | Spiro-oxazolones | 豪夫迈·罗氏有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105793266-A | Spiro-oxazolones | 豪夫迈·罗氏有限公司 | 2016-07-20 | — | — | CN | disclosed |