Potassium Ion — predicted protein targets

Known targets — ChEMBL curated mechanism

AGTR1 DHFR GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GART NR3C2 PBP2X PTGS1 PTGS2 VKORC1 bla blaT-3 blaT-4 blaT-5 blaT-6 dacA dacB dacC folA ftsI mrcA mrcB mrdA pbp1a pbp1b pbp2a pbp2b pbp3 pol thyA

The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	GABRP known ✓	O00591	1/20	0.33

▸	GABRD known ✓	O14764	1/20	0.33

▸	GABRA1 known ✓	P14867	1/20	0.33

▸	GABRB1 known ✓	P18505	1/20	0.33

▸	GABRG2 known ✓	P18507	1/20	0.33

▸	GABRB3 known ✓	P28472	1/20	0.33

▸	GABRA5 known ✓	P31644	1/20	0.33

▸	GABRA3 known ✓	P34903	1/20	0.33

▸	GABRA2 known ✓	P47869	1/20	0.33

▸	GABRB2 known ✓	P47870	1/20	0.33

▸	GABRA4 known ✓	P48169	1/20	0.33

▸	GABRE known ✓	P78334	1/20	0.33

▸	GABRA6 known ✓	Q16445	1/20	0.33

▸	GABRG1 known ✓	Q8N1C3	1/20	0.33

▸	GABRG3 known ✓	Q99928	1/20	0.33

▸	GABRQ known ✓	Q9UN88	1/20	0.33

▸	CYP3A4	P08684	4/20	0.42

▸	TSHR	P16473	3/20	0.42

▸	MAPK1	P28482	1/20	0.42

▸	TDP1	Q9NUW8	6/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2810183	0.96	TDP1 (0.42)	CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL2813599	0.77	KDM4E (0.52)	CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL2807685	0.76	KDM4E (0.50)	CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL2810184	0.76	KDM4E (0.50)	CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL30568720	0.74	KDM4E (0.45)	CYP3A4TDP1MAPTALDH1A1KDM4E
Pyromellitic Acid SCHEMBL413317	0.72	KDM4E (0.42)	TDP1ALDH1A1KDM4EPOLB
SCHEMBL2811951	0.72	KDM4E (0.53)	CYP3A4TSHRMAPK1MAPTALDH1A1
SCHEMBL13365081	0.71	KDM4E (0.50)	CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL19161558	0.71	TSHR (0.50)	CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL274410	0.71	GABRP (0.52)	CYP3A4TSHRMAPK1TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20100240908-A1	ACETYLENE COMPOUND	FUJIFILM CORPORATION (JP)	2010-09-23	—	—	US	disclosed
EP-2202221-A1	ACETYLENE COMPOUND	Fujifilm Corporation (JP)	2010-06-30	—	—	EP	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20100240908-A1	ACETYLENE COMPOUND	NAT1, KATNA1, KAT2B	GABRP 4331/4885GABRD 4245/4885GABRA1 2372/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.