SCHEMBL28080828

SCHEMBL28080828

O=CC(=O)c1c(-c2ccccc2)c(-c2ccccc2)cn1Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 8/20 0.46
ESR1 P03372 1/20 0.41
SIGMAR1 Q99720 1/20 0.40
PGR P06401 1/20 0.39
MEN1 O00255 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.39
TBXA2R P21731 1/20 0.39
PTGER1 P34995 1/20 0.39
PTGER4 P35408 1/20 0.39
PTGFR P43088 1/20 0.39
PTGER3 P43115 1/20 0.39
PTGER2 P43116 1/20 0.39
PTGIR P43119 1/20 0.39
PTGDR Q13258 1/20 0.39
FAAH O00519 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28080903 0.88 ALDH1A1 (0.43) ESR1MEN1HTTKMT2A
SCHEMBL28080836 0.88 F2RL3 (0.39)
SCHEMBL28080894 0.86 ALDH1A1 (0.47) CCR2SIGMAR1HTT
SCHEMBL28080891 0.82 ALDH1A1 (0.44) MEN1CYP3A4CYP2D6CYP2C19KMT2A
SCHEMBL28080843 0.81 CYP11B1 (0.44) HTTFAAH
SCHEMBL28080966 0.81 GFER (0.46) SIGMAR1MEN1KMT2A
SCHEMBL28831826 0.79 AR (0.41) MEN1KMT2A
SCHEMBL27962502 0.77 HDAC4 (0.37) CYP2D6CYP2C9CYP2C19
SCHEMBL28831769 0.77 GFER (0.46) SIGMAR1MEN1CYP3A4CYP2D6CYP2C9
SCHEMBL28080830 0.76 TUBB4A (0.46) MEN1CYP3A4CYP2C9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103804108-B A kind of method preparing primary amine 沈阳药科大学 2016-08-03 CN disclosed