SCHEMBL28831769

SCHEMBL28831769

COc1ccc(-c2cn(Cc3ccccc3)c(C(=O)C=O)c2-c2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GFER P55789 1/20 0.46
LMNA P02545 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CHRM1 P11229 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
RAB9A P51151 3/20 0.42
MAPK8 P45983 1/20 0.41
NPC1 O15118 2/20 0.41
PLA2G2A P14555 1/20 0.41
F2RL3 Q96RI0 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
EP300 Q09472 1/20 0.40
EDNRB P24530 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
SIGMAR1 Q99720 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28080966 0.95 GFER (0.46) GFERLMNAALDH1A1CHRM1RAB9A
SCHEMBL28080836 0.88 F2RL3 (0.39) LMNAALDH1A1MAPK8F2RL3
SCHEMBL27962501 0.87 ICMT (0.43) GFERLMNAALDH1A1CHRM1MEN1
SCHEMBL28080844 0.84 TUBB4A (0.44) GFERMEN1KMT2AL3MBTL1
SCHEMBL27962502 0.81 HDAC4 (0.37) CYP1A2CYP2D6CYP2C9CYP2C19NPC1
SCHEMBL28080830 0.81 TUBB4A (0.46) ALDH1A1CYP3A4CYP2C9MEN1KMT2A
SCHEMBL28080903 0.81 ALDH1A1 (0.43) LMNAALDH1A1MEN1KMT2A
SCHEMBL28080894 0.79 ALDH1A1 (0.47) LMNAALDH1A1L3MBTL1SIGMAR1
SCHEMBL28080843 0.77 CYP11B1 (0.44) LMNAALDH1A1
SCHEMBL28080828 0.77 CCR2 (0.46) CYP3A4CYP2D6CYP2C9CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103804108-B A kind of method preparing primary amine 沈阳药科大学 2016-08-03 CN disclosed