Water

Water

SCHEMBL28087308

CC(=O)OCCCN(C)C.O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM5 known ✓ P08912 3/20 0.45
CHRM1 known ✓ P11229 3/20 0.45
CHRM3 known ✓ P20309 3/20 0.45
CHRM2 known ✓ P08172 2/20 0.45
CHRM4 known ✓ P08173 2/20 0.45
HTR1A known ✓ P08908 1/20 0.41
ALDH1A1 P00352 6/20 0.54
RAD52 P43351 1/20 0.51
GAA P10253 2/20 0.47
CHRNB2 P17787 2/20 0.45
CHRNA4 P43681 2/20 0.45
TSHR P16473 3/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.41
PGR P06401 1/20 0.41
TBXA2R P21731 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA7 P36544 1/20 0.41
CHRNA10 Q9GZZ6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26314 0.98 ALDH1A1 (0.56) ALDH1A1RAD52GAACHRM5CHRM1
Ammonia Solution, Strong SCHEMBL7710348 0.95 ALDH1A1 (0.54) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL761115 0.91 ALDH1A1 (0.54) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL31440319 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL31297301 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL8756090 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL34462071 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL31440233 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL31440349 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1
SCHEMBL31440335 0.89 ALDH1A1 (0.52) ALDH1A1RAD52GAACHRM5CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105813721-B Device for dispensing particles in small volumes 不列颠哥伦比亚大学 2019-11-05 CN disclosed
CN-108064294-A Hepatitis B virus (HBV) iRNA compositions and methods of use thereof 阿尔尼拉姆医药品有限公司 2018-05-22 CN disclosed
CN-107533076-A Continuous stream microfluid system 不列颠哥伦比亚大学 2018-01-02 CN disclosed
CN-105813721-A Device for dispensing particles in small volumes 不列颠哥伦比亚大学 2016-07-27 CN disclosed