Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | XIAP | P98170 | 2/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31480604 | 0.83 | KDM4E (0.62) | ALDH1A1KDM4ELMNAGRM5SMN1; SMN2 | |
| SCHEMBL15652792 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAGRM5SMN1; SMN2 | |
| SCHEMBL23964983 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAGRM5SMN1; SMN2 | |
| Potassium Ion SCHEMBL16834389 | 0.80 | SMN1; SMN2 (0.43) | ALDH1A1KDM4ELMNAGRM5SMN1; SMN2 | |
| SCHEMBL12541310 | 0.75 | TDP1 (0.44) | ALDH1A1KDM4ELMNASMN1; SMN2HCAR3 | |
| SCHEMBL38656393 | 0.75 | KDM4E (0.70) | ALDH1A1KDM4ELMNAGRM5SMN1; SMN2 | |
| Potassium Ion SCHEMBL18167990 | 0.72 | PTGER1 (0.39) | ALDH1A1KDM4EPTGER1BRD4 | |
| Dipicolinic Acid SCHEMBL7699646 | 0.71 | KDM4E (0.56) | ALDH1A1KDM4EPTGER1 | |
| Dipicolinic Acid SCHEMBL674980 | 0.71 | KDM4E (0.56) | ALDH1A1KDM4EPTGER1 | |
| Dipicolinic Acid SCHEMBL9753719 | 0.71 | KDM4E (0.56) | ALDH1A1KDM4EPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106170486-B | Novel indazolecarboxamides, method for the production thereof, pharmaceutical preparations containing the same and use thereof for producing medicaments | 拜耳医药股份有限公司 | 2019-01-15 | — | — | CN | disclosed |
| CN-106170486-A | Novel indazolecarboxamides, method for the production thereof, pharmaceutical preparations containing the same and use thereof for producing medicaments | 拜耳医药股份有限公司 | 2016-11-30 | — | — | CN | disclosed |