Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28021906 | 0.94 | TSHR (0.40) | TSHRDNM1HTTKMT2AHSP90AA1 | |
| Hydrochloric Acid SCHEMBL20295228 | 0.82 | TSHR (0.41) | TSHRHSP90AA1RAD52TDP1ALDH1A1 | |
| SCHEMBL188119 | 0.82 | TSHR (0.41) | TSHRHSP90AA1RAD52TDP1ALDH1A1 | |
| Iodide SCHEMBL9750243 | 0.79 | TSHR (0.39) | TSHRHSP90AA1RAD52TDP1ALDH1A1 | |
| Bromide SCHEMBL31013627 | 0.79 | TSHR (0.39) | TSHRKMT2AHSP90AA1RAD52TDP1 | |
| Pivalate SCHEMBL9012070 | 0.79 | BBOX1 (0.46) | DNM1HTTKMT2ABBOX1 | |
| Water SCHEMBL28099730 | 0.78 | TSHR (0.40) | TSHRRAD52BBOX1TDP1ALDH1A1 | |
| SCHEMBL14981464 | 0.78 | DNM1 (0.40) | TSHRDNM1HTTHSP90AA1RAD52 | |
| SCHEMBL5806773 | 0.76 | PSMD14 (0.47) | DNM1HTTKMT2AHSP90AA1RAD52 | |
| Water SCHEMBL3302970 | 0.76 | DNM1 (0.39) | TSHRDNM1HTTKMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105986308-B | Electrolyte composition for removing flash and method for removing flash | 化研科技株式会社 | 2018-04-13 | — | — | CN | disclosed |
| CN-105986308-A | Electrolyte composition for removing flash and method for removing flash | 化研科技株式会社 | 2016-10-05 | — | — | CN | disclosed |