Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PTPRC | P08575 | 2/20 | 0.54 |
| ▸ | PTPRG | P23470 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 5/20 | 0.54 |
| ▸ | CA4 | P22748 | 5/20 | 0.54 |
| ▸ | CA12 | O43570 | 4/20 | 0.54 |
| ▸ | CA1 | P00915 | 4/20 | 0.54 |
| ▸ | CA6 | P23280 | 4/20 | 0.54 |
| ▸ | CA7 | P43166 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30016005 | 0.88 | PTPRC (0.68) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL18769941 | 0.85 | PTPRC (0.54) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL30016479 | 0.85 | PTPRC (0.54) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL911071 | 0.82 | MEN1 (0.64) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL29295506 | 0.82 | L3MBTL1 (0.52) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL17927526 | 0.82 | PTPRC (0.51) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL292247 | 0.81 | KMT2A (0.61) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL17927618 | 0.80 | PTPRC (0.49) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL11820877 | 0.79 | PTPRG (0.69) | KMT2AMEN1POLBALDH1A1CYP1A2 | |
| SCHEMBL8484203 | 0.76 | PTGES (0.49) | KMT2AMEN1POLBALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| CN-106008488-B | Cyanoindole analog derivative and its preparation method and application | 广东东阳光药业有限公司 | 2018-10-30 | — | — | CN | disclosed |
| CN-106008488-A | Cyan indoles derivative and preparation method and use thereof | 广东东阳光药业有限公司 | 2016-10-12 | — | — | CN | disclosed |