Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28837021 | 0.87 | MAPT (0.60) | MAPTTP53DHODHLMNAKDM4E | |
| SCHEMBL28115569 | 0.85 | KDM4E (0.50) | MAPTTP53DHODHLMNAKDM4E | |
| SCHEMBL28115022 | 0.84 | DHODH (0.53) | MAPTTP53DHODHALOX5KDM4E | |
| SCHEMBL28115477 | 0.84 | RXFP1 (0.52) | MAPTTP53LMNAKDM4ETDP1 | |
| SCHEMBL28115074 | 0.84 | DHODH (0.54) | MAPTDHODHKDM4ETDP1L3MBTL1 | |
| SCHEMBL28837077 | 0.81 | TRPV1 (0.43) | MAPTDHODHLMNAKDM4ETDP1 | |
| SCHEMBL28115474 | 0.80 | MAPT (0.60) | MAPTTP53LMNAKDM4ETDP1 | |
| SCHEMBL28115475 | 0.76 | MAPT (0.45) | MAPTTP53DHODHLMNAKDM4E | |
| SCHEMBL28115476 | 0.76 | POLB (0.57) | MAPTTP53LMNAKDM4ETDP1 | |
| SCHEMBL28115023 | 0.74 | MAPT (0.46) | MAPTDHODHLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220560-A | A kind of preparation method of poly-substituted quinoline derivant | 华侨大学 | 2016-12-14 | — | — | CN | disclosed |