SCHEMBL28129052

SCHEMBL28129052

CC(C)(C)[Si](C)(C)OCc1ccc(-c2cc[nH]n2)cc1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DUT P33316 2/20 0.33
METAP2 P50579 1/20 0.31
PREP P48147 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9905184 0.77 ALPL (0.35)
SCHEMBL20029088 0.75 DUT (0.35) DUT
SCHEMBL17440111 0.75 NAAA (0.42) PREP
SCHEMBL12002628 0.74 IDO1 (0.46) DUTPREP
SCHEMBL5221804 0.74 IDO1 (0.35) DUTPREP
SCHEMBL12783776 0.74 IDO1 (0.35) DUTPREP
SCHEMBL7216378 0.74 WNT3A (0.33)
SCHEMBL10176696 0.73 METAP2 (0.55) METAP2
SCHEMBL906834 0.73 IDO1 (0.48)
SCHEMBL12855670 0.73 AGXT (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103476252-B Pyrazolyl guanidine F1F 0-ATPase inhibitors and therapeutic uses thereof 莱斯拉公司 2017-02-22 CN disclosed