Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5153811 | 0.82 | PDK1 (0.49) | SMN1; SMN2TSHRPDK1PDK2PDK3 | |
| SCHEMBL2244779 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL7450832 | 0.80 | RAB9A (0.51) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10673838 | 0.79 | ALDH1A1 (0.46) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| Trifluoroacetic Acid SCHEMBL27745571 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL4436187 | 0.77 | PDK1 (0.53) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| Fluoride SCHEMBL10887137 | 0.76 | PDK1 (0.51) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL23240942 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL6002669 | 0.75 | NAPRT (0.59) | SMN1; SMN2TSHRTP53EPHX1EPHX2 | |
| SCHEMBL9065932 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRTP53EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409531-A1 | BENZOXAZINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS | MERCK SHARP & DOHME LLC (US) | 2024-12-12 | — | — | US | disclosed |
| CN-107849008-A | A kind of octahydro pentamethylene simultaneously [c] azole derivatives and preparation method thereof and purposes in medicine | 四川海思科制药有限公司 | 2018-03-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240409531-A1 | BENZOXAZINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS | NFATC1, ACIN1, GZMB | SMN1; SMN2 2567/4885TSHR 4793/4885TP53 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.