Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29001803 | 0.81 | ALDH1A1 (0.54) | MAPTLMNAHTTNPSR1MAPK1 | |
| SCHEMBL315684 | 0.76 | HTR6 (0.54) | ALDH1A1KMT2AHTR6 | |
| SCHEMBL30343460 | 0.75 | MAPT (0.54) | MAPTLMNAS1PR4S1PR1HTT | |
| SCHEMBL2679084 | 0.75 | MAPT (0.54) | MAPTLMNAS1PR4S1PR1HTT | |
| SCHEMBL150811 | 0.75 | HTR6 (0.38) | KMT2AHTR6PRSS1 | |
| SCHEMBL2458633 | 0.74 | HTR6 (0.58) | MAPTLMNAS1PR4S1PR1HTT | |
| SCHEMBL10438578 | 0.74 | PTGS2 (0.40) | MAPTLMNAHTTALDH1A1KMT2A | |
| SCHEMBL5146128 | 0.74 | HSD11B1 (0.45) | PGRALDH1A1HSD11B1 | |
| SCHEMBL310695 | 0.74 | GAA (0.54) | MAPTHTTNPSR1ALDH1A1KMT2A | |
| SCHEMBL10438542 | 0.73 | KMT2A (0.44) | MAPTLMNAHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104619328-B | The condensed quinoline alkane glucocorticoid receptor modulator of heteroaryl -one | 科赛普特治疗学股份有限公司 | 2018-10-02 | — | — | CN | claimed |
| CN-104619328-B | The condensed quinoline alkane glucocorticoid receptor modulator of heteroaryl -one | 科赛普特治疗学股份有限公司 | 2018-10-02 | — | — | CN | disclosed |