Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28259952 | 0.84 | PTPN1 (0.52) | SMN1; SMN2KDM4EPOLBHDAC8HDAC6 | |
| SCHEMBL28866664 | 0.81 | PTPN1 (0.52) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL27972549 | 0.80 | SMO (0.53) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL27972606 | 0.76 | KDM4E (0.51) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL27972353 | 0.76 | NAMPT (0.51) | NPC1RAB9AMAPTLMNASMN1; SMN2 | |
| SCHEMBL27972318 | 0.76 | PTPN1 (0.48) | NPC1MEN1KMT2AMAPTLMNA | |
| SCHEMBL27972313 | 0.75 | KCNJ5 (0.50) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL28261352 | 0.75 | CHRNB2 (0.45) | NPC1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL28813725 | 0.74 | GRM1 (0.46) | KDM4E | |
| SCHEMBL27972571 | 0.74 | EPHX2 (0.48) | NPC1RAB9AMAPK1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108863959-B | P2X4 receptor antagonists | 日本化学药品株式会社 | 2021-11-30 | — | — | CN | disclosed |
| CN-111333588-A | P2X4 receptor antagonists | 日本化学药品株式会社 | 2020-06-26 | — | — | CN | disclosed |
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |