Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 4/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27972606 | 0.79 | KDM4E (0.51) | KDM4EPOLBMAPTNPC1RAB9A | |
| SCHEMBL27972621 | 0.79 | NPC1 (0.42) | KDM4EPOLBMAPTF2F10 | |
| SCHEMBL27972550 | 0.79 | GRM1 (0.43) | GRM1GRM4KDM4EPOLBMAPT | |
| SCHEMBL27972312 | 0.78 | AVPR2 (0.45) | NPC1RAB9A | |
| SCHEMBL28866664 | 0.77 | PTPN1 (0.52) | KDM4EPOLBMAPTNPC1RAB9A | |
| SCHEMBL27972293 | 0.77 | RAB9A (0.54) | KDM4EPOLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28813725 | 0.77 | GRM1 (0.46) | GRM1GRM4KDM4E | |
| SCHEMBL27972308 | 0.77 | MEN1 (0.50) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28426457 | 0.77 | CHRNB2 (0.43) | POLBSMN1; SMN2 | |
| SCHEMBL27972271 | 0.76 | RAB9A (0.53) | ROCK2ROCK1KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483423-A | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO | 2019-11-22 | — | — | CN | disclosed |
| CN-108863959-A | P2X4 RECEPTOR ANTAGONIST | 日本化学药品株式会社 | 2018-11-23 | — | — | CN | disclosed |